Cellular Triggers of Asthma Attack 

"Your Can't Understand your Asthma Attacks Until You
Understand Cellular Triggers..."

Asthma is a serious chronic disease and still little is known about cellular triggers of asthma attack.

.......The possible causes of the attacks are so varied that it's really difficult to determine exactly what the cellular triggers of an asthma attack are.

While the symptoms are well known, the mechanism of the disease is still well hidden from our eyes.

The difference between general causes and cellular triggers of an asthma attack

It is important to remember that causes and triggers are two different terms and even if we know the causes of the disease, we may have no idea about the cellular triggers of an asthma attack.

The possible causes are more or less obvious: pollen, cold, inhaling cold air, stress, physical exercise, genetics… All of them can cause the attack and every asthmatic quickly discovers what can bring on an asthma attack. But cellular triggers - impulses that are directly responsible for the beginning of an asthma attack - are still unclear.

What forces muscles to limit the airflow? What chemical or biological triggers are responsible for that?

IgE and allergens

The first theory about cellular triggers of an asthma attack blames IgE (immunoglobulin E) for starting an inflammatory response that closes the airways. It is produced as a part of the allergic response of a human organism on certain substances it is allergic to.

The substances (pollen, certain food, some chemicals) cause little or no response in people who don't suffer from the allergy. The theory is strengthened by the fact that over 90% of asthmatic teenagers have a large quantity of IgE in their blood during the attack.

The only problem is that it's not the case with adult asthmatics (only 50% of them have too much IgE in their blood).

Even if IgE is really one of the cellular triggers of an asthma attack, it is certainly not the only one capable of causing the attacks. What starts them when there is only little IgE?

 Inflammation

The only thing known for sure is that whatever the cellular triggers of an asthma attack are, they are certainly connected to the process of airways inflammation. Whatever it is, it causes muscles to tighten. There is little more known about it.

There are several research groups working on the problem now, but so far they haven't produced any results. Stayed tuned for more news soon.

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Cellular Triggers of Asthma Attack